Treatment with 150 mg losartan reduced the risk of hospitalisation for heart failure by 13.5% relative to 50 mg losartan (p=0.025 95% confidence interval 0.76-0.98). In three patients with a pre-treatment plasma creatinine level above 3 mg/dl, a progressive deterioration of renal function was observed and Losartan was withdrawn after 10, 11 and 15 months, respectively. Conclusions: Losartan treatment promotes to BP decrease and improvement of renal function, and also maintenance reduction in plasma CRP and UA which significantly associated with renal function index – GFR in EH pts with hypertensive CKD. 2019 May 17;10:64. doi: 10.4103/ijpvm.IJPVM_278_17.  |  In conclusion, we want pointed out that losartan could affect renal function in a similar way as angiotensin converting enzyme inhibitors (ACEI). It is also used for diabetic kidney disease, heart failure, and left ventricular enlargement. Int J Prev Med. Renal arteriography did not demonstrate significant stenosis in any of these cases. 1996;146(11):228-31. 1995 Nov;9 Suppl 5:S55-8. So, it might not have been the losartan as such but a failure to correct the losartan's tendency to increase the amount of fluid passing through the kidneys. Would you like email updates of new search results? Angiotensin receptor blockers are renoprotective in hypertensive azotemic patients with type 2 diabetes, but their efficacy in early diabetic kidney disease is uncertain.  |  Tablets are available in 25 mg, 50 mg, and 100 mg dosages. NIH It comes as an oral tablet. Clipboard, Search History, and several other advanced features are temporarily unavailable. The dynamics of BP, GFR and plasma IRI, CRP and UA concentrations under 12-months losartan treatment are presented in the table. 1994 Dec;39(12 Suppl 1):397-400. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. What is Renal failure acute? COVID-19 is an emerging, rapidly evolving situation.  |  Enalapril versus losartan for adults with chronic kidney disease: A systematic review and meta‐analysis. Renal failure acute (rapid kidney dysfunction) has been reported by people with high blood pressure, type 2 diabetes, diabetes, pain. The angiotensin II receptor antagonist losartan: a new advance in the treatment of hypertension. NCI CPTC Antibody Characterization Program. The first signs, however, look promising, since losartan appears to induce changes in several identified risk factors to the same extent as ACE inhibitors, such as renal vasodilation, and a fall in proteinuria and serum lipids. NIH National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Please enable it to take advantage of the complete set of features! Kidney Int. High-potassium foods and chronic kidney disease (CKD) ... after a heart attack to help individuals with heart failure who cannot tolerate ACE inhibitors and treat non-diabetic kidney disease (UpToDate, n.d.). A new class of therapeutic agents: the angiotensin II receptor antagonists. Add-on angiotensin II receptor blockade lowers urinary transforming growth factor-beta levels. The challenge will be to discover the differences between ACE inhibitors and Ang II receptor antagonists and to use them to the future advantage of the renal patient. HHS Others include lifestyle and dietary changes. Clipboard, Search History, and several other advanced features are temporarily unavailable. 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